The HML2 subfamily of HERV-K (henceforth HERV-K) represents the most recently endogenized retrovirus in the human genome.While Flashlight the products of certain HERV-K genomic copies are expressed in normal tissues, they are upregulated in several pathological conditions, including various tumors.It remains unclear whether HERV-K(HML2)-encoded pro
Jingfen Sun, Zhengshen Zhou Department of Ophthalmology, Ruijin Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China Background: The aim of the study was to develop a sustained ocular delivery of brinzolamide (BLZ) based on gellan gum.Methods: The formulations were characterized for cl
Abstract Objectives To investigate how many traditional Chinese medicine (TCM) guidelines adopted a grading system and the differences among them, and the distribution of level of evidence used to support TCM recommendations.Methods A comprehensive search of relevant guideline webpages and literature databases were undertaken from inception to Augu
The problem of aligning multiple biological sequences has fascinated scientists for a long time.Over the last four decades, tens of heuristic-based Multiple Sequence Alignment (MSA) tools have been proposed, the vast majority being built on the concept of Progressive Alignment.It is known, however, that this approach suffers from an inherent drawba